Effect of PI‐HAART on the prevalence of oral lesions in HIV‐1 infected patients. A Greek study
- 6 April 2004
- journal article
- Published by Wiley in Oral Diseases
- Vol. 10 (3) , 145-150
- https://doi.org/10.1046/j.1601-0825.2003.00994.x
Abstract
To investigate the association between the prevalence of oral lesions and highly active antiretroviral therapy (HAART) including a protease inhibitor (PI). Prospective study. Ninety-five consecutive patients, attending an AIDS Unit, in Greece entered the study. Fourty-four patients were receiving PI- HAART, 14 patients were on double antiretroviral therapy, and 37 patients were not receiving antiretroviral therapy at the time of oral examination. Oral lesions were diagnosed by established presumptive clinical criteria. Oral lesions were scored. CD4 counts and viral load were determined and related to the prevalence of oral lesions. Oral lesions, and specifically oral candidiasis, were significantly reduced (P < 0.001) in patients receiving PI-HAART. Oral lesions were significantly increased in patients with CD4 counts 20,000 copies ml(-1) (P < 0.001). The percentage of patients, with lesions on PI-HAART, and with CD4 < 200 and viral load >20,000 was 1.5 times lower (37.5%vs 58.8%, P < 0.001) than that of patients not receiving antiretroviral therapy, but with similar immune and viremic status. Oral lesions were significantly reduced in patients on PI-HAART. A direct anticandidal effect of PI was suggestive and seemed to have accounted, beyond the HAART-related immune reconstitution, for the reduction of candidiasis and all other oral lesions.Keywords
This publication has 22 references indexed in Scilit:
- Paucity of Sjogren-like syndrome in a cohort of HIV-1-positive patients in the HAART era. Part IIRheumatology, 2003
- Oral manifestations of an HIV positive cohort in the era of highly active anti‐retroviral therapy (HAART) in South LondonJournal of Oral Pathology & Medicine, 2002
- Antiretroviral Therapy with Protease Inhibitors Has an Early, Immune Reconstitution–Independent Beneficial Effect onCandidaVirulence and Oral Candidiasis in Human Immunodeficiency Virus–Infected SubjectsThe Journal of Infectious Diseases, 2002
- The effect of antiretroviral therapy on the prevalence of oral manifestations in HIV-infected patients: A UK studyOral Surgery Oral Medicine Oral Pathology Oral Radiology and Endodontology, 2001
- Effect of highly active antiretroviral therapy on frequency of oral wartsThe Lancet, 2001
- Oral Lesions in HIV/AIDS Patients Undergoing Highly Active Antiretroviral Treatment Including Protease Inhibitors: A New Face of Oral AIDS?AIDS Patient Care and STDs, 2000
- Decline in the rate of oral opportunistic infections following introduction of highly active antiretroviral therapyJournal of Oral Pathology & Medicine, 2000
- Oral lesions and conditions associated with human immunodeficiency virus infection in 300 south Indian patientsOral Diseases, 2000
- Epidemiological shifts in opportunistic and nosocomial Candida infections: mycological aspectsInternational Journal of Antimicrobial Agents, 1996
- Classification and diagnostic criteria for oral lesions in HIV infectionJournal of Oral Pathology & Medicine, 1993