PLATELET CHANGES AFTER PLACEMENT OF AORTIC PROSTHESES IN DOGS .2. IMPAIRED SURFACE-INDUCED ARTERIAL THROMBOSIS
- 1 January 1981
- journal article
- research article
- Vol. 97 (3) , 360-368
Abstract
An experimental preparation was developed to assess changes in surface-induced arterial thrombosis in 9 dogs with woven Dacron aortic prostheses. The preparation consisted in measuring the occlusion time of an A-V [arteriovenous] shunt with controlled flow rate (200 ml/min). This measurement depended on formation of an occlusive, platelet-rich thrombus on a diaphragm of polyester mesh. Two to 6 mo. after placement of thoracoabdominal aortic prostheses, all animals demonstrated striking prolongation of A-V shunt occlusion time. This occurred in the presence and absence of heparin anticoagulation. No change in A-V shunt occlusion time was noted in dogs who had sham operations. These findings complement studies showing biochemical and functional changes in circulating platelets in dogs with aortic prostheses and together they are consistent with mild platelet damage sufficient to impair surface-induced thrombosis. In dogs, platelets apparently interact reversibly with prosthetic surfaces.This publication has 3 references indexed in Scilit:
- PLATELET CHANGES AFTER PLACEMENT OF AORTIC PROSTHESES IN DOGS .1. BIOCHEMICAL AND FUNCTIONAL ALTERATIONS1981
- EFFECT OF SHEAR RATE ON PLATELET INTERACTION WITH SUBENDOTHELIUM IN CITRATED AND NATIVE BLOOD .2. RELATIONSHIPS AMONG PLATELET-ADHESION, THROMBUS DIMENSIONS, AND FIBRIN FORMATION1980
- INVITRO ASSESSMENT OF INTERACTION OF BLOOD WITH MODEL SURFACES1978