Experimental Coliform (Aerobacter Aerogenes) Mastitis: Distribution of Whey Proteins During the Early Acute Phase

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Abstract
The paper electrophoretic distribution of whey proteins was determined during the course of both mild and severe mastitis caused by the infusion of two million Aerobacter aerogenes into various lactating glands. In either case, evidence of increased permeability between blood and milk took place by 3 hours. The serum albumin content of whey peaked by ten hours rapidly returning to normal levels. The immune globulin fraction remained elevated for as long as 16 days following inoculation and for as long as two weeks following return of the glands to normal This suggests the two proteins are transudated by different mechanisms. Following an agalactic phase in the acute disease a protein with a mobility intermediate between a-lactalbumin and immune globulin appeared in high concentration and which disappeared as the glands returned to normal milk production. A similar protein was observed in dry cow secretions.