EFFECT OF AURANOFIN ON DNA AND PROTEIN-SYNTHESIS IN HUMAN LYMPHOCYTES

  • 1 January 1977
    • journal article
    • research article
    • Vol. 4  (3) , 245-251
Abstract
The effect of auranofin, a new oral gold compound for the treatment of rheumatoid arthritis, and gold sodium thiosulfate on DNA and protein synthesis, as well as their effect on membrane transport in stimulated lymphocytes was studied. Only auranofin in the given concentrations apparently inhibits incorporation of 3H-thymidine and 14C-amino acids. The pharmacological action of auranofin might be mediated through its action at the cellular membrane level.