Inhibition of Synthesis of the Cell Wall of Staphylococcus aureus by Cephalothin
- 20 February 1964
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 143 (3608) , 807-808
- https://doi.org/10.1126/science.143.3608.807
Abstract
Cephalothin, 7-(thiophene-2-acetamido)-cephalosporanic acid, suppresses synthesis of the cell of Staphylococcus aureus. Exposure to this agent led to a reduction in the degree of incorporation of carbon-14-lysine into the mucopeptide of the cell wall material and to an accumulation of N-acetyl glucosamine in the cell. The intensity of the lesions was comparable to that produced by penicillin.Keywords
This publication has 3 references indexed in Scilit:
- NEW PENICILLINS, CEPHALOSPORIN C, AND PENICILLINASE1961
- A Fractionation Procedure for Studies of the Synthesis of Cell-Wall Mucopeptide and of Other Polymers in Cells of Staphylococcus aureusJournal of General Microbiology, 1960
- A MODIFIED COLORIMETRIC METHOD FOR THE ESTIMATION OF N-ACETYLAMINO SUGARSJournal of Biological Chemistry, 1955