PROSTAGLANDIN-E2 PRODUCTION BY RENOMEDULLARY TISSUE OF DOCA, GOLDBLATT AND SPONTANEOUSLY HYPERTENSIVE RATS

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  • 1 January 1976
    • journal article
    • research article
    • Vol. 15  (4) , 753-765
Abstract
The relationship between in vitro prostaglandin [PG] production by renal medullary tissue and hypertension was investigated in 3 models of hypertensive rat, i.e., DOCA [deoxycorticosterone], Goldblatt and SHR [spontaneously hypertensive rats]. Medullary minces were incubated for 30 min. Following incubation tissue PGE2 concentration was quantified using mass fragmentography. Media PGE2 concentrations were quantified using radioimmunoassay. Concentrations of PGE2 in tissue from Goldblatts and SHR were significantly less than normotensive controls. The concentration of PGE2 in media after incubating SHR tissue was significantly less than in normotensives. Alterations in PGE2 metabolism may be similar to Goldblatt and SHR hypertension.