Effects of a new adenosine deaminase inhibitor, isocoformycin, on toxicity, antitumor activity and tissue distribution of formycin A and 9-.BETA.-D-arabinofuranosyladenine.
- 1 January 1980
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 33 (3) , 303-309
- https://doi.org/10.7164/antibiotics.33.303
Abstract
Single i.p. and i.v. injections of 1200 mg/kg isocoformycin did not cause the death of mice. Isocoformycin inhibited adenosine deaminase and significantly enhanced the toxicity of formycin A and ara-A [9-.beta.-D-arabinofuranosyladenine] at various combination ratios. Isocoformycin potentiated the antitumor activity of formycin A and ara-A against [mouse] L-1210 leukemia cells. Formycin A and ara-A disappeared rapidly from the blood and tissues and could not be found in any tissues 0.5 h after a single i.p. injection. When used in combination with isocoformycin, both were detected in the blood and tissues, especially at high concentration in liver and kidney. The deamination of formycin A and ara-A is probably blocked by isocoformycin in vivo.This publication has 6 references indexed in Scilit:
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