Study of protolytic, hydrolytic and solubility equilibria of midazolam
- 1 January 1995
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in The Analyst
- Vol. 120 (8) , 2145-2151
- https://doi.org/10.1039/an9952002145
Abstract
Protolytic equilibria of midazolam in the pH range 0–12 were investigated. Acidity, hydrolysis, equilibrium constants in the heterogeneous system and the solubility of midazolam were determined [I= 0.1 mol l–1(NaCl), 25 °C]. A spectrophotometric method was developed for the investigation of the mechanism of hydrolysis and the determination of the corresponding equilibrium constants. In addition, buffer characteristics of the two-phase and single-phase midazolam buffers were investigated.Keywords
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