A clinical experience with cefadroxil in upper respiratory tract infection

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Abstract
In a series of studies, cefadroxil was compared with other antibiotics for the treatment of acute tonsillopharyngitis caused by β-haemolytic streptococci. In a double-blind study comparing cefadroxil with penicillin, all patients improved within 24 h of initiation of therapy. The overall clinical and bacteriological cure rates were significantly different (P < 001). Children treated with cefadroxil had a combined cure rate of 96% while those given penicillin were found to have a combined rate of 81 %. There were no failures among patients who received cefadroxil, but there were two among patients given penicillin. In a second study in which cefadroxil was compared with penicillin V, benzathine and procaine penicillin G, and erythromycin estolate, all patients improved within 24 h of initiation of therapy. Reinfection with a new group A β-haemolytic streptococcal serotype occurred in 13 patients, 12 developing 7 to 12 days after stopping therapy and 11 becoming symptomatic. Relapse with the same organism occurred in 16 patients, only 5 (31%) of whom were symptomatic. Antibody titre rises, antibiotic resistance of group A organisms, presence of penicillinase-producing staphylococci, and lack of compliance were not related to recurrent infections. There were no significant differences between the failure rates of the four test drugs penicillin V (12%), benzathine and procaine penicillin G (12%), cefadroxil monohydrate (5%), and erythromycin (2%).

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