Determination of the homologue composition of some alkyltrimethyl quaternary ammonium antibacterial agents by gas chromatography

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Abstract
RECENT work has shown that the micellar properties of quaternary ammonium surface-active agents may be linked with their antibacterial action (Weiner, Hart & Zografi, 1965). Micelle formation and antibacterial activity both depend markedly on the chain length of the hydrocarbon groups attached to the quaternary nitrogen, and other biological properties may also depend on this aspect of their structure (Hart & Nissim, 1966). Commercially produced materials are mixtures of homologues and a method is described below for measuring the homologue composition.