Osteochondrodystrophia Deformans with Mucopolysaccharidosis

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Abstract
A family with increased urinary excretion of acid mucopolysaccharides is described. In 2 of the cases radiological changes in the spine were found, like those of Morquio-Brails-ford''s disease, though the clinical appearances of the patients are normal. Bone biopsy from one of the 2 patients showed increasec content of acid mucopolysaccharides. Even mild forms of Morquio-Brailsford''s disease are due to an inborn error of metabolism as in Morquio-Ullrich''s disease and gargoylism.