Effect of Lipid-Lowering Drug Therapy on Small-Dense Low-Density Lipoprotein

1 March 2005

journal article
review article
Published by SAGE Publications in Annals of Pharmacotherapy

Vol. 39 (3) , 523-526
https://doi.org/10.1345/aph.1e322

Abstract

OBJECTIVE: To review the effects of lipid-lowering therapy on small-dense low-density lipoprotein cholesterol (sdLDL-C). DATA SOURCES: Literature was obtained from MEDLINE (1989–September 2004) and references of selected articles. Key search terms included small-dense LDL-C and lipid-lowering drug therapy. DATA SYNTHESIS: Statins, fibrates, and niacin have demonstrated favorable effects on sdLDL-C, especially among patients with mixed dyslipidemia or hypertriglyceridemia. These effects include a reduction of sdLDL-C and/or a shift to the larger, less atherogenic LDL-C. CONCLUSIONS: Data suggest that statins, fibrates, and niacin are effective at reducing concentrations of sdLDL-C and possibly normalizing LDL-C subclasses.

Keywords

DRUG THERAPY

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