Multiple forms of fructose diphosphate aldolase in mammalian tissues.
- 1 October 1966
- journal article
- research article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 56 (4) , 1275-1282
- https://doi.org/10.1073/pnas.56.4.1275
Abstract
A new fructose diphosphate aldolase termed ''aldolase C'' was isolated from rabbit brain. Aldolase C can be distinguished from aldolase A and B by its catalytic properties, electrophoretic and chromatographic properties, and its immunochemical characteristics. Antibodies prepared against aldolase A and B do not cross-react with aldolase C. Five-membered aldolase sets including 3 hybrid forms are produced in vitro by reversible dissociation of a mixture of any 2 of the parental aldolases (A, B, or C). All 5 members of the A-C set can be produced on reversible dissociation of a single crystalline hybrid of the A-C set. Such hybrid forms are found in vivo in tissues which contain more than 1 parental aldolase type. The number of hybrid forms (3) can be easily reconciled with an enzyme composed of 4 similar subunits, but not with 3 chain models of the enzyme.This publication has 8 references indexed in Scilit:
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