The Effect of Mercurial Diuretics on the Excretion of Water

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Abstract
In experiments on 11 normal subjects and on three dogs it has been observed that mercurial diuretics do not prevent the stimulation of water absorption and formation of hypertonic urine which characteristically follows the infusion of Pitressin. Furthermore mercurial diuretics only rarely increase urine flow when administered in the course of maximal water diuresis. These two facts are interpreted as meaning that the diuretic agents have no primary effect on the reabsorption of water. Rather, increased urine flow results secondarily from increased elimination of ions.