Phosphosugars are potent inhibitors of central nervous system inflammation 1
- 1 June 1989
- journal article
- research article
- Published by Wiley in The FASEB Journal
- Vol. 3 (8) , 1968-1971
- https://doi.org/10.1096/fasebj.3.8.2721857
Abstract
Adoptively transferred allergic encephalomyelitis can be inhibited by various phosphosugars, particularly mannose-6-phosphate. The sugar specificity suggests that inhibition may be due to depletion of lymphocyte cell-surface lysosomal enzymes, which are essential for the passage of lymphocytes across the vascular endothelium and the entry of lymphocytes into the central nervous system parenchyma.—Willenborg, D. O.; Parish, C. R.; Cowden, W. B. Phosphosugars are potent inhibitors of central nervous system inflammation. FASEB J. 3: 1968-1971; 1989.Keywords
Funding Information
- National Health and Medical Research Council
- National Multiple Sclerosis Society
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