Working Model of the Sympathetic Chemoreflex in Rats
- 1 January 1995
- journal article
- review article
- Published by Taylor & Francis in Clinical and Experimental Hypertension
- Vol. 17 (1-2) , 167-179
- https://doi.org/10.3109/10641969509087063
Abstract
This review examines the neural network responsible for activation of the sympathetic vasomotor system during stimulation of carotid chemoreceptors (CC) in anesthetized vagotomized rats (sympathetic chemoreflex, SChR). Based on unit recording studies and experiments designed to impair synaptic transmission within selected lower brainstem nuclei or subregions, a model of the SChR is proposed with the essential features: i) key role of the nucleus of the solitary tract (NTS), rostral ventrolateral medulla (RVL) and ventrolateral pons (A5 area), ii) no role for caudal ventrolateral medulla (CVL), iii) modulatory role of dorsolateral pons and pre-Botzinger area, iv) dual control of bulbospinal presympathetic (preS) cells by CC inputs, one via the central respiratory network and the other through a direct excitatory pathway independent of the activity of this network, and v) independent medullary pathways for SChR and baroreflex until the preS neuronal stage in RVL.Keywords
This publication has 10 references indexed in Scilit:
- Projections from the nucleus tractus solitarii to the spinal cordJournal of Comparative Neurology, 1993
- The projections of noradrenergic neurons in the A5 catecholamine cell group to the spinal cord in the rat: anatomical evidence that A5 neurons modulate nociceptionBrain Research, 1993
- Ventrolateral medulla and sympathetic chemoreflex in the ratBrain Research, 1993
- Absence of respiration modulation of carotid sinus nerve inputs to nucleus tractus solitarius neurons receiving arterial chemoreceptor inputsJournal of the Autonomic Nervous System, 1993
- Pre-Bötzinger Complex: a Brainstem Region that May Generate Respiratory Rhythm in MammalsScience, 1991
- Role of the Ventral Medulla Oblongata in Blood Pressure RegulationPublished by Oxford University Press (OUP) ,1990
- Arterial baroreceptor reflex: Its central and peripheral neural mechanismsProgress in Neurobiology, 1990
- Chapter 4 Central control of the circulation by the rostral ventrolateral reticular nucleus: anatomical substratesPublished by Elsevier ,1989
- Relationship between sympathetic and phrenic nerve responses to peripheral chemoreflex in the catJournal of the Autonomic Nervous System, 1988
- Evidence for direct projections from the nucleus of the solitary tract onto medullary adrenaline cellsJournal of Comparative Neurology, 1988