Pharmacokinetics and Tissue Disposition of the Off-Flavor Compound 2-Methylisoborneol in the Channel Catfish (Ictalurus punctatus)

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Abstract
The tissue disposition of the off-flavor compound 2-methylisoborneol (MIB) was examined in market-sized channel catfish (Ictalurus punctatus). Purified MIB was intravascularly administered to channel catfish at a dosage of 1 mg .cntdot. kg-1 body weight. Body tissues and fluid were collected at intervals following administration and were analyzed for MIB by microwave distillation and capillary gas chromatography. Plasma clearance of MIB was characterized by a two-compartment open model with half-lives of 0.14 and 3.62 h for distribution and elimination phases, respectively. MIB was more concentrated in peritoneal fat and subepidermal adipose tissue than in other tissues. The concentration in the edible flesh decrased from 0.107 .mu.g .cntdot. g-1 at 2 h to 0.025 .mu.g .cntdot. g-1 at 96 h. There was no evidence of biotransformation of MIB to the related compounds 2-methylenebornane and 2-methyl-2-bornene over the 96-h sampling period. The low recoveries of the administered dose in body fluids and tissues and the rapid clearance suggested significant gill excretion of this compound.