DNA methylation in Trypanosoma cruzi
- 9 April 1990
- journal article
- Published by Wiley in FEBS Letters
- Vol. 263 (1) , 113-116
- https://doi.org/10.1016/0014-5793(90)80717-w
Abstract
DNA isolated from the protozoan Trypanosoma cruzi has been found to contain 5‐methylcytosine. Analysis of T. cruzi DNA by both HpaII and MspI restriction endonucleases suggests that the sequence ‐CCGG‐ is not methylated. Probably T. cruzi DNA also contains N6‐methyladenine. This report constitutes the first clear demonstration of the presence of methylated bases in the nuclear DNA from trypanosomes.Keywords
This publication has 25 references indexed in Scilit:
- Nucleoside analysis of DNA from Trypanosoma brucei and Trypanosoma equiperdumMolecular and Biochemical Parasitology, 1988
- Multiple Trypanosoma cruzi antigens containing tandemly repeated amino acid sequence motifsMolecular and Biochemical Parasitology, 1988
- 5-Azacytidine, DNA Methylation, and DifferentiationPublished by Springer Nature ,1984
- DNA Methylation in Friend Erythroleukemia Cells: The Effects of Chemically Induced Differentiation and of Treatment with Inhibitors of DNA MethylationPublished by Springer Nature ,1984
- DNA METHYLATION AND GENE ACTIVITYAnnual Review of Biochemistry, 1983
- DNA Methylation and Gene FunctionScience, 1980
- Isolation and characterization of kinetoplast DNA from bloodstream form of Trypanosoma brucei.The Journal of cell biology, 1978
- Methylated bases in DNA from Paramecium aureliaBiochimica et Biophysica Acta (BBA) - Nucleic Acids and Protein Synthesis, 1974
- [6N]METHYL ADENINE IN THE NUCLEAR DNA OF A EUCARYOTE, TETRAHYMENA PYRIFORMIS The Journal of cell biology, 1973
- Nuclear and Kinetoplastic DNA from Trypanosomes*The Journal of Protozoology, 1969