Studies on Pyrazolo [3, 4-d] pyrimidine Derivatives. VIII. On Syntheses and Anti-tumor Activity of 4-Amino-1-(o-, m- or p-nitrophenyl)-1H-pyrazolo [3, 4-d] pyrimidines and Their Derivatives
Open Access
- 1 January 1977
- journal article
- research article
- Published by Pharmaceutical Society of Japan in YAKUGAKU ZASSHI
- Vol. 97 (12) , 1328-1333
- https://doi.org/10.1248/yakushi1947.97.12_1328
Abstract
4-Amino-1-(o-, m-, or p-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidine and 41 kinds of their derivatives were synthesized and the compounds were screened for antitumor activity against Ehrlich carcinoma [mouse]. Antitumor activity was found in 4-elaidamido-1-(o-nitrophenyl)-1H-pyrazolo[3,4-d]pyrimidine and 4-oleamido-1-(p-nitrophenyl) compound.Keywords
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