Cyclophosphamide-Induced Spermatogenic Effects Detected in the F 1 Generation by Behavioral Testing
- 2 January 1981
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 211 (4477) , 80-82
- https://doi.org/10.1126/science.7444453
Abstract
Fischer 344 male rats were treated with cyclophosphamide (10 milligrams per kilogram of body weight) for 5 weeks and subsequently mated to females previously treated with saline or cyclophosphamide. The F1 progeny of the cyclophosphamide-treated males exhibited behavior deficits when compared to controls. These data could indicate a chemically induced genetic effect manifested by behavioral alterations.This publication has 5 references indexed in Scilit:
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