EFFECT OF HIGH PRESSURE OXYGEN ON THE UPTAKE OF DL-LYSINE-H BY BRAIN AND OTHER TISSUES OF THE RAT

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Abstract
DL-lysine-H3 was injected intrave ously into rats subjected to high pressure oxygen (HPO-3 atmospheres; 2 above normal atmospheric pressure) and into control rats not subjected to HPO. A depression of uptake of labeled materials was noted in all parts of the brain, the pineal, adrenal, cardiac muscle, liver and thyroid in HPO-treated rats. No specific pattern of change in uptake was noted in the pituitary lobes, or skeletal muscle. Since incorporation of labeled materials appeared somewhat higher in the plasma proteins of the HPO-treated rats than in the controls, one possible explanation for the decrease in uptake in other organs or tissues of HPO-treated rats could be due to an increased utilization of the injected labeled amino acid in the synthesis of plasma proteins. The ischemia induced by HPO may also be involved in that it too could reduce the availability of the amino acid for protein synthesis.