(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase
- 1 July 1999
- journal article
- letter
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 42 (15) , 2741-2746
- https://doi.org/10.1021/jm9902584
Abstract
No abstract availableThis publication has 25 references indexed in Scilit:
- Diversity of the Pyruvate Dehydrogenase Kinase Gene Family in HumansJournal of Biological Chemistry, 1995
- Characterization of cellular defects of insulin action in type 2 (non-insulin-dependent) diabetes mellitus.Journal of Clinical Investigation, 1993
- Lactate Production and Pyruvate Dehydrogenase Activity in Fat and Skeletal Muscle From Diabetic RatsDiabetes, 1992
- Fasting Hyperglycemia Normalizes Oxidative and Nonoxidative Pathways of Insulin-Stimulated Glucose Metabolism in Noninsulin-Dependent Diabetes Mellitus*Journal of Clinical Endocrinology & Metabolism, 1990
- Effect of starvation and insulin in vivo on the activity of the pyruvate dehydrogenase complex in rat skeletal musclesFEBS Letters, 1989
- Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinaseBiochemical Journal, 1988
- Short Term Regulation of Mouse Pyruvate Dehydrogenase Complex by InsulinHormone and Metabolic Research, 1981
- Amino acid sequences around the sites of phosphorylation in the pig heart pyruvate dehydrogenase complexBiochemical Journal, 1979
- Sites of phosphorylation on pyruvate dehydrogenase from bovine kidney and heartBiochemistry, 1978
- Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversionArchives of Biochemistry and Biophysics, 1971