CGMP STIMULATION OF STEM-CELL PROLIFERATION

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  • 1 January 1977
    • journal article
    • research article
    • Vol. 49  (4) , 585-591
Abstract
The effect of various nucleotides and stimulators of nucleotide synthesis upon the formation of in vitro granulocyte colonies [mouse] was examined. Physiologic concentrations of cyclic[c]GMP enhanced the formation of granulocyte-macrophage colonies in the presence of colony-stimulating activity. The cells sensitive to cGMP activation were resistant to thymidine suicide and could not be activated by colony-stimulating activity alone. The cGMP sensitive stem cell was apparently an ordinarily resting stem cell which was triggered into a proliferative state by cGMP.