Effect of Age and Caloric Restriction on Cutaneous Wound Closure in Rats and Monkeys
Open Access
- 1 March 1997
- journal article
- research article
- Published by Oxford University Press (OUP) in The Journals of Gerontology: Series A
- Vol. 52A (2) , B98-B102
- https://doi.org/10.1093/gerona/52a.2.b98
Abstract
Cutaneous wounds close more slowly in rats and monkeys as age increases. Caloric restriction of 40% in rats and 30% in monkeys did not significantly affect healing rates, although it did exert a trend toward faster closure. Similarly, voluntary exercise did not significantly alter healing rates in rats. Thus, impaired wound healing appears to be a generalized physiological manifestation of aging, but its possible amelioration by “anti-aging” interventions remains to be established.Keywords
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