Studies with Three Alkylating Agents as House Fly Sterilants

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Abstract
Three radiomimetic compounds[long dash]aphoxide (tris(l-aziridinyl)-phosphine oxide), aphomide (N,N[image] -ethylenebis[P ,P-bis(1 -aziridinyl)-N-methylphosphinic amide]), and apholate (2,2,4,4,6,6-hexa(l-aziridinyl)2,4,6-triphospha-1,3,5-triazine)[long dash]caused sterility in male and female house flies (Musca domestica L.) at concentrations of 1% to 0.5% in food given to adults. The greatest effect in tests with apholate was caused by feeding on the first day after emergence. When a mixed population of normal males and males treated with aphoxide or apholate were caged with normal females some of the eggs laid were viable and some nonviable, but with aphomide the eggs were mostly viable. Male flies given apholate for 5 days mated readily with normal females and their sperm were motile and appeared to be effective in zygote formation. Normal females caged first with treated and then with untreated males laid only non-viable eggs, whereas females mated first to normal and then to treated males laid only viable eggs. In tests utilizing rooms, flies given untreated food produced 40,088 pupae, those given food treated with 1% of apholate produced 86 to 226 pupae, and those given a choice of food produced 13 to 121 pupae.

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