Progressive Cortical Change During Adolescence in Childhood-Onset Schizophrenia
Open Access
- 1 July 1999
- journal article
- research article
- Published by American Medical Association (AMA) in Archives of General Psychiatry
- Vol. 56 (7) , 649-654
- https://doi.org/10.1001/archpsyc.56.7.649
Abstract
THE neurodevelopmental hypothesis of schizophrenia suggests that a brain "lesion" is present early in life but does not manifest itself until late adolescence or early adulthood.1-3 Compelling clinical support for this model comes from numerous demonstrations of subtle but consistent abnormalities in cognitive and behavioral development noted years before the onset of psychosis.4-6 In addition, the postmortem neuropathological findings in schizophrenia can be viewed as consistent with an early nonprogressive event.2Keywords
This publication has 2 references indexed in Scilit:
- Implications of Normal Brain Development for the Pathogenesis of SchizophreniaArchives of General Psychiatry, 1987
- Synaptic density in human frontal cortex — Developmental changes and effects of agingBrain Research, 1979