Calculation of the Dose-rate Dependence of the Dicentric Yield after Co γ-irradiation of Human Lymphocytes
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in International Journal of Radiation Biology
- Vol. 35 (3) , 229-233
- https://doi.org/10.1080/09553007914550261
Abstract
The dose relation for dicentrics after in vitro Co γ-irradiation of human lymphocytes with dose rates of 50 and 1·7 rad/min fit the linear-quadratic function y = αD + βD2. Compared with 50 rad/min, after 1·7 rad/min αD was unchanged, whereas βD2 was decreased by 36 per cent. By applying the mean interaction time t˜ ≈ 110 min for primary breaks, determined in an earlier experiment, and Lea's G-function, a theoretical dose relation for 1·7 rad/min can be calculated from the dose relation of the higher dose rate. This theoretical function is not significantly different from the corresponding experimental curve. Thus, from calibration curves with conventional dose rates dose–effect curves for low dose rates can be derived without the need for time-consuming chromosome analyses.This publication has 12 references indexed in Scilit:
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