REGULATION OF THE MURINE IGE ANTIBODY-RESPONSE .1. CHARACTERIZATION OF SUPPRESSOR CELLS REGULATING BOTH PERSISTENT AND TRANSIENT RESPONSES AND THEIR SENSITIVITY TO LOW-DOSES OF X-IRRADIATION

  • 1 January 1979
    • journal article
    • research article
    • Vol. 123  (6) , 2791-2798
Abstract
Anti-ovalbumin (OA) Ig[immunoglobulin]E antibody responses were measured in B6D2F1 mice as a function of time and antigen dose. OA (100-200 .mu.g) in Al(OH)3 elicited transient responses. OA (1-10 .mu.g) in Al(OH)3 elicited persistent anti-OA IgE responses of high titer. T [thymus-derived] cells isolated from the spleens of mice mounting a persistent or transient response strongly suppressed primary anti-DNP [dinitrophenol] IgE responses in unirradiated recipient mice immunized with DNP-OA in Al(OH)3. Suppressor T cells (TS cells) were activated during persistent and transient IgE responses. IgG antibodies may suppress the IgE response. With a modified adoptive transfer system, these TS cells were sensitive to low doses (250 R) of X-irradiation. Suppressive activity of long-term OA primed cells was markedly enhanced when cultured for 24 h with soluble OA; this finding may indicate presence of memory suppressor cells.

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