Serotonin receptors on pulmonary alveolar macrophages

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Abstract
Summary Pulmonary alveolar macrophages harvested from the albino mouse lung were shown to possess surface receptor sites capable of binding physiological concentrations of serotonin (5-hydroxytryptamine). These specific, high affinity binding sites showed temperature-dependent kinetics with a single order high affinity binding site for serotonin. The presence of serotonin receptors on pulmonary alveolar macrophages provides a basis for relating at least one mediator of pulmonary inflammatory processes and transport processes to effects upon the macrophage surface.

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