Effect of Cimetidine and Pyrilamine on Histamine-Induced Ocular Surface Hyperemia
- 1 January 1986
- journal article
- research article
- Published by Mary Ann Liebert Inc in Journal of Ocular Pharmacology and Therapeutics
- Vol. 2 (3) , 275-278
- https://doi.org/10.1089/jop.1986.2.275
Abstract
Histamine-induced ocular surface redness was virtually abolished by a combination of cimetidine (H2-receptor antagonist) and pyrilamine (H1-receptor antagonist), whereas either antagonist administered alone produced no significant reduction. It appears that combined H1- and H2-antagonist therapy is required for effective blockade of ocular responses to histamine that involve both receptor subtypes.Keywords
This publication has 2 references indexed in Scilit:
- Ocular disposition of topically applied histamine, cimetidine, and pyrilamine in the albino rabbitCurrent Eye Research, 1984
- H2-Receptors in the Human Ocular SurfaceArchives of Ophthalmology (1950), 1981