Experimental Allergic Encephalomyelitis Following Administration of Homologous Brain Lipid Fractions

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Abstract
Various procedures for making encephalitogenic extracts of brain material were repeated and the extracts tested under control conditions. Results failed to confirm previous reports that a nonlipid substance was capable of inducing experimental allergic encephalomyelitis. Encephalitogenic activity could not be shown in either a calcium acetate extract or a water dialysate of defatted brain. Several lipid solvents were tested, and only chloroform yielded an extract with activity in producing encephalitis. However, the residue, after chloroform extraction, still possessed encephalitogenic activity. From this it was postulated that there are 2 "antigens" present in brain which can produce encephalomyelitis.

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