Generation of Prothrombin Activity With Mitochondria or With Cathepsin

Publisher Website
Google Scholar
Abstract
Prothrombin activity can be regenerated from ‘inactive’ prothrombin in the presence of either liver mitochondria or cathepsin concentrates obtained from spleen or liver. This regeneration of prothrombin occurs more rapidly near ph 7.9. Mitochondria and cathepsin may also accelerate destruction of prothrombin activity. This occurs in acid solutions, and at ph 5 such destruction is very pronounced. Either mitochondria or cathepsin can be used under similar conditions for producing apparently identical changes in prothrombin. Most likely the agent in mitochondria which participates in the generation of prothrombin activity from a precursor is cathepsin.

This publication has 1 reference indexed in Scilit: