The Metalation of Fluoroanisoles: Optional Regioselectivity Due to Metal Mediated Control
- 1 January 1991
- journal article
- letter
- Published by Georg Thieme Verlag KG in Synlett
- Vol. 1991 (10) , 731-732
- https://doi.org/10.1055/s-1991-34754
Abstract
2- and 4-Fluoroanisole undergo hydrogen/metal exchange at the position next to the alkoxy moiety if butyllithium or tert-butyllithium is employed and at the position next to the halogen atom if the stoichiometric mixture of butyllithium and potassium tert-butoxide serves as the reagent. 3-Fluoroanisole is always attacked at the position flanked by the two heterosubstituents.Keywords
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