Structural and functional domains in human tumour necrosis factors

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Abstract
Human tumour necrosis factors (hTNFs) α and β are related pleiotropic cytokines which share many activities and compete with each other for binding to two receptor components on many cell types. Although structural and biological data indicate that the active form of hTNF-α may be a symmetrical trimer, the manner in which hTNFs interact with their receptors to trigger a myriad of cell type-dependent responses is not clear. A combination of chemical modification, epitope mapping and site-directed mutagenesis approaches suggest that at least four distinct peptide sequences are Important for the biological activity of hTNF-α. In particular, certain peptide sequences between amino acid positions 11 and 35 in hTNF-α appear to be critical for receptor binding and triggering biological responses. The recent cloning of the two hTNF-α/β receptors opens the way for precise mapping of the functional domains in hTNFs

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