Linked aryl aryloxypropanolamines as a new class of lipid catabolic agents

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Abstract
The synthesis of a series of stilbene, biaryl, tolane, diaryl ether, sulfide, sulfoxide and sulfone oxypropanolamines as potential antiobesity agents is described. These compounds were evaluated in a mouse lipid catabolism screen, and the more active members of the series were further investigated in rats and dogs. 1-(2,6-Di-tert-butyl-4-trans-styrylphenoxyl)-3-isopropylamino-2-propanol possessed considerable lipid catabolic activity in mice and caused a significant reduction in the body weight of rats after 5 wk and of dogs after 6 wk. Only hematological irregularities in a chronic toxicity study precluded further development of this compound as an alternative antiobesity treatment.

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