FATTY ACID ETHYL ESTER FORMATION BY PLASMA IN VITRO
- 1 February 1966
- journal article
- research article
- Published by Canadian Science Publishing in Canadian Journal of Biochemistry
- Vol. 44 (2) , 219-227
- https://doi.org/10.1139/o66-026
Abstract
The capacity of rat plasma to form ethyl esters when incubated with ethanol and fatty acid was examined. The process was found to be enzymatic and to involve primarily a direct esterification of fatty acid as opposed to a transesterification requiring a fatty acyl donor. Maximal esterification of oleic acid occurred at pH 6.0 but significant activity existed at physiological pH to indicate a capacity of the plasma to utilize ethanol and fatty acid in concentrations that might be expected in vivo. Both normal and post-heparin plasma were found to esterify endogenous free fatty acid. A major factor affecting the esterification process was the availability of fatty acid substrate and the governing role of plasma albumin in this respect is discussed.This publication has 2 references indexed in Scilit:
- Partition of fatty acids of 20–24 carbon atoms between serum albumin and lipoproteinsBiochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism, 1965
- Post-Heparin Lipolytic Activity Following Intravenous Heparin-S35Experimental Biology and Medicine, 1965