Vascular responses in mesenteric arteries from genetic and renal hypertensive rats

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Abstract
Mesenteric arteries isolated from a colony of rats bred to develop hypertension spontaneously, from rats with experimental renal hypertension; and from normotensive controls were perfused at constant flow with blood or physiological saline. Vasoconstrictor responses to norepinephrine and angiotensin were higher in mesenteric arteries from genetic hypertensive rats than in similar preparations from weight-matched normotensive controls. Perfusion pressures were higher in unstimulated mesenteric arteries from genetic hypertensive rats than in control preparations. Mesenteric arteries from rats with renal hypertension also exhibited both higher vasoconstrictor responses to norepinephrine and higher perfusion pressure base lines than did control preparations. The association of higher responses to vasoconstrictor drugs and increased resistance to flow in blood vessels from hypertensive animals is discussed.