Studies on the Metabolism of the Antioxidant Ethoxyquin, 6-Ethoxy-2,2,4-Trimethyl-1,2-Dihydroquinoline in the Rat
- 1 January 1979
- journal article
- research article
- Published by Taylor & Francis in Xenobiotica
- Vol. 9 (11) , 649-657
- https://doi.org/10.3109/00498257909042332
Abstract
1. The metabolism of ethoxyquin (6-ethoxy-2,2,4-trimethyl-1, 2-dihydroquinoline) in rat has been investigated. Urinary metabolites were identified by combined g.l.c.-mass spectrometry. 2. The major metabolic reaction was de-ethylation which gave rise to 6-hydroxy-2,2,4-trimethyl-1,2-dihydroquinoline and an oxidation product, 2,2,4-trimethyl-6-quinolone. Other reactions were hydroxylation to four different hydroxylated metabolites and one dihydroxylated metabolite. A total of 95% of the dose (100mg/kg) was accounted for.This publication has 4 references indexed in Scilit:
- The Distribution of 14C‐Ethoxyquin in RatActa Pharmacologica et Toxicologica, 1979
- Thermische Reaktionen im Massenspektrometer Modellreaktionen zur Untersuchung thermischer Umalkylierungen. 11. Mitteilung über das massenspektrometrische Verhalten von StickstoffverbindungenHelvetica Chimica Acta, 1969
- Absorption and Distribution of Vitamin E in the TissuesPublished by Elsevier ,1962
- Feedstuffs Antioxidants, Absorption, Metabolism, and Excretion of the Antioxidant, 6-Ethoxy-1,2-dihydro-2,2,4-trimethylquinolineJournal of Agricultural and Food Chemistry, 1959