Effect of Dietary Sucrose and Fructose on the Metabolism and Lipid Fractions in Liver in the Rat

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Abstract
Male and female weanling rats were fed one of the following diets for 26 weeks: 60 % (w/w) starch as control (59 % of energy content); 20 (20), 40 (39) or 60 % (59 %) sucrose; or 20 % (20 %) fructose. With increasing levels of dietary sucrose the livers of male rats but not those of females, were progressively heavier. Livers of rats of both sexes showed progressively higher total lipid levels mainly as a result of high triglyceride levels. The 20 % fructose diet produced the same effect as the 40 % sucrose diet. The incorporation of 14C-glucose into liver lipids in vitro, and the production of 14CO2 were both depressed by sucrose and fructose feeding in both sexes.