Method Development and Selectivity Control for Small Molecule Pharmaceutical Separations by Capillary Electrophoresis

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Abstract
This manuscript outlines an approach for capillary electrophoresis (CE) method development. It is applied to small molecule pharmaceutical separations using analgesics as examples. the effect of various parameters on selectivity are evaluated, and some recommendations are made regarding successful quantitation. Such parameters as linearity, sensitivity, and reproducibility are also examined. This knowledge is extended to other application areas, and examples of CE separations for such compounds as penicillins, water soluble vitamins, and enantiomeric compounds are presented. It is shown that the selectivity, sensitivity, and reproducibility of CE are adequate for routine use in the pharmaceutical laboratory.