Mitochondrial toxicity of antiviral drugs
- 1 May 1995
- journal article
- review article
- Published by Springer Nature in Nature Medicine
- Vol. 1 (5) , 417-422
- https://doi.org/10.1038/nm0595-417
Abstract
Long-term treatment with antiviral nucleoside analogue drugs, such as AZT, can give rise to delayed and at times severe mitochondrial toxicity. Although these toxic effects are manifest in many tissues, a common disease mechanism can explain the diverse clinical events. A better understanding of these disorders will shed light on genetic mitochondrial diseases and lead to the design of safer and more effective antiviral drugs.Keywords
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