Regulation of progesterone secretion by LH and prolactin during the first half of pregnancy in the mouse

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Abstract
Pregnant mice were treated with LH [luteinizing hormone, lutropin] antiserum or bromocriptine to inhibit the activity of LH and prolactin, respectively. Luteal function was monitored by the radioimmunoassay of plasma progesterone. Bromocriptine treatment on days 2 or 5 of pregnancy produced a rapid decrease in progesterone secretion, but had no effect on luteal function when given on days 6, 7 or 8 of gestation. Treatment with LH antiserum before implantation did not inhibit progesterone secretion but luteal function was severely impaired when the antiserum was given on days 5-9 of pregnancy. The dynamic nature of luteal dependency on prolactin and LH was demonstrated. Apparently LH is an essential component of the luteotrophic complex of the mouse.

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