Response to Comment on "Diverse Psychotomimetics Act Through a Common Signaling Pathway"

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Abstract
It is widely accepted that d-amphetamine, LSD, and PCP directly or indirectly affect multiple neurotransmitter receptors and transporters. Amphetamine, owing to its dopamine-releasing properties, indirectly activates postsynaptic D1 and D2 receptors. However, D1 and D2 receptor agonists have opposing actions on DARPP-32 phosphorylation: We reported that D2 receptor agonists decreased phospho-Thr34-DARPP-32 and increased phospho-Thr75-DARPP-32 (7-9). Seeman's proposition that our results can be explained solely by D2 receptor agonism is inconsistent with the current data and predicts results opposite to those found in (5).