Pulmonary Reaction Associated with Transfusion of Plasma Containing Anti‐5b

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Abstract
A patient developed an acute respiratory distress syndrome with lung infiltrates during a transfusion of plasma. The transfused plasma was shown to contain a potent leucocyte agglutinating antibody of IgG type with anti-5b specificity, reactive with the patient''s cells. A review of the literature on similar transfusion-related syndromes showed an association with more or less well-defined white cell antibodies, mainly in the donors'' plasma. The majority of donors were multiparous women. The anti-5b in our donor was demonstrated only by granulocyte agglutination technique, as previously described antibodies in the five system. A long incubation procedure (20-25 h) seemed to be optimal for granulocyte agglutination.