CHANGES IN PLASMA NORADRENALINE CONCENTRATION AS A MEASURE OF RELEASE RATE
Open Access
- 1 October 1978
- journal article
- Published by Wiley in British Journal of Pharmacology
- Vol. 64 (2) , 305-309
- https://doi.org/10.1111/j.1476-5381.1978.tb17305.x
Abstract
1 A method is described for repeated sampling of plasma noradrenaline (NA) in freely moving rats. Na concentration does not change during the day or after adrenalectomy. 2 Exogenous NA has a half-life of 1.5 min; drugs which block neuronal and extra-neuronal uptake lengthen this to 6.3 min. 3 Swim-stress leads to a steep rise followed by a rapid decline in plasma NA concentration. 4 This method of plasma NA sampling can serve as a measure of both steady and rapid changes in release rate over long periods of time.Keywords
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