EFFECTS OF SOYBEAN PHOSPHATIDES ON THE HEMORRHAGIC TENDENCY DUE TO THROMBOCYTOPENIA*

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Abstract
The effects on red cell diapedesis in thrombocytopenic dogs (x-irradiation) of a preparation of soybean phosphatides (RG-"Lecithin"- Glidden) capable of replacing in vitro the coagulation promoting activity of platelets were studied by observation of the output of red blood cells in the lymph. The intravenous administration of 200 mg/kg phosphatides, homogenized in isotonic saline, to 11 thrombocytopenic dogs resulted in rapid but temporary (2 to 3 hours) reduction of the output of red cells into the lymph collected from the left main thoracic duct. In 3 animals complete return of the hemorrhagic lymph to normal appearance and red cell content, occurred. The change was comparable to this observed following transfusions of fresh platelets. In 10 of the total 11 animals the reduction of bleeding into the lymph ranged from 80 to 97%. A control group of 10 animals given isotonic saline under similar conditions showed a steady increase of the output of red cells. Statistical analysis of the data indicated a p value of 0.0005 regarding the difference between the phosphatides and saline treated group. The prolonged bleeding time was not changed in either group.