PROLIFERATING CELL NUCLEAR ANTIGEN EXPRESSION IN CHILDHOOD ACUTE-LEUKEMIA
- 1 September 1990
- journal article
- research article
- Vol. 76 (5) , 985-990
Abstract
Proliferating cell nuclear antigen (PCNA) is a 36-Kd nuclear protein, identified as the auxillary protein of DNA polymerase .delta., that is upregulated in activated proliferating cells from a variety of tissues and species, including human lymphocytes. We have examined by two-dimensional polyacrylamide gel electrophoresis the expression of PCNA in various subtypes of childhood acute leukemia and have found differences in its expression according to subtype. These differences were not related to the initial peripheral white blood count, age, or sex, and appeared to reflect differences in proliferative activity between subtypes of acute leukemia.This publication has 14 references indexed in Scilit:
- Inhibition of Cellular Proliferation by Antisense Oligodeoxynucleotides to PCNA CyclinScience, 1988
- PROLIFERATING CELL NUCLEAR ANTIGEN (PCNA)/CYCLIN IN ACTIVATED HUMAN LYMPHOCYTES-T1987
- Cloning and sequence of the human nuclear protein cyclin: homology with DNA-binding proteins.Proceedings of the National Academy of Sciences, 1987
- A comparison of some adjustment techniques for use with quantitative spot data from two‐dimensional gelsElectrophoresis, 1987
- Purification and N-terminal amino acid sequence of proliferating cell nuclear antigen (PCNA)/cyclin and development of ELISA for anti-PCNA antibodies.The Journal of Immunology, 1985
- Cell-cycle-specific genes differentially expressed in human leukemias.Proceedings of the National Academy of Sciences, 1985
- Changes in the nuclear distribution of cyclin (PCNA) but not its synthesis depend on DNA replication.The EMBO Journal, 1985
- Proliferating Cell Nuclear Antigen in Blast Crisis Cells of Patients With Chronic Myeloid Leukemia23JNCI Journal of the National Cancer Institute, 1984
- Ultrasensitive Stain for Proteins in Polyacrylamide Gels Shows Regional Variation in Cerebrospinal Fluid ProteinsScience, 1981
- PRETREATMENT CYTOKINETIC STUDIES IN 94 CHILDREN WITH ACUTE-LEUKEMIA - RELATIONSHIP TO OTHER VARIABLES AT DIAGNOSIS AND TO OUTCOME OF STANDARD TREATMENT1977