Lennox-Gastaut Syndrome (Childhood Epileptic Encephalopathy)
- 1 November 2003
- journal article
- review article
- Published by Wolters Kluwer Health in Journal Of Clinical Neurophysiology
- Vol. 20 (6) , 426-441
- https://doi.org/10.1097/00004691-200311000-00005
Abstract
Lennox-Gastaut syndrome (LGS) is a childhood epileptic encephalopathy characterized by an electroclinical triad of generalized slow spike wave (SSW) activity in the EEG, multiple types of epileptic seizures, and slow mental development. It is usually subdivided into symptomatic and cryptogenic types, the latter accounting for at least one fourth of all patients. Symptomatic cases are due to diverse cerebral conditions, which are usually bilateral, diffuse, or multifocal, involving cerebral gray matter. Twenty percent of all patients with LGS have prior infantile spasms with hypsarrythmia. The characteristic interictal EEG pattern of LGS is 1.5 to 2.5 Hz SSW activity, which is bilaterally synchronous, dominant over the frontocentral regions, and usually symmetric. There are varying degrees of slowing of the background. Sleep discloses paroxysms of generalized fast (10 to 25 Hz) rhythmic activity.Keywords
This publication has 45 references indexed in Scilit:
- Nonconvulsive Status Epilepticus - A Possible Cause of Mental Retardation in Patients with Lennox-Gastaut SyndromeNeuropediatrics, 2000
- Topiramate in Lennox–Gastaut Syndrome: Open‐Label Treatment of Patients Completing a Randomized Controlled TrialEpilepsia, 2000
- Electroclinical Seizures in Lennox-Gastaut SyndromeEpilepsia, 1993
- The Axial Spasm—The Predominant Type of Drop Seizure in Patients with Secondary Generalized EpilepsyEpilepsia, 1985
- Epilepsies with Diffuse Slow Spikes and Waves of Late OnsetEuropean Neurology, 1983
- Generalized paroxysmal fast activity: Electroencephalographic and clinical featuresAnnals of Neurology, 1982
- Petit Mal Status in Early Childhood and DementiaNeuropediatrics, 1979
- GENERALIZED SHARP AND SLOW WAVE COMPLEXES ASSOCIATED CLINICAL FEATURES AND LONG-TERM FOLLOW-UPBrain, 1973
- Centrencephalic Myoclonic-Astatic Petit Mal1– Clinical and genetic investigationsNeuropediatrics, 1970
- Childhood Epileptic Encephalopathy with Diffuse Slow Spike‐Waves (otherwise known as “Petit Mal Variant”) or Lennox SyndromeEpilepsia, 1966