Effect ofPhyllanthus amarus on duck hepatitis B virus replication in vivo
- 1 December 1990
- journal article
- research article
- Published by Wiley in Journal of Medical Virology
- Vol. 32 (4) , 212-218
- https://doi.org/10.1002/jmv.1890320404
Abstract
Nine ducks congenitally infected with the duck hepatitis B virus (DHBV) were treated either orally (four ducks for 10 weeks) or intraperitoneally (five ducks for 12 weeks) with the Indian traditional herbal remedy Phyllanthus amarus. Compared to placebo-treated control ducks, these treatments did not result in a reduction of circulating viral DNA in the serum or in the level of viral DNA replication in the liver. In two of the five intraperitoneal-treated ducks, a reduction in the levels of duck hepatitis B surface antigenaemia (DHBsAg) was observed. The data strongly suggest that Phyllanthus amarus has no significant inhibitory effect on DHBV DNA replication and only a minor effect on DHBsAg production.Keywords
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