Inactivated products of rifampicin by pathogenic Nocardia spp.: Structures of glycosylated and phosphorylated metaholites of rifampicin and 3-formylrifamycin SV.
- 1 January 1993
- journal article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 46 (10) , 1605-1610
- https://doi.org/10.7164/antibiotics.46.1605
Abstract
Rifampicin (1) was converted into four inactivated products by pathogenic Nocardia, RIP-1 and RIP-2 by N. brasiliensis and RIP-3 and RIP-4 by N. otitidiscaviarum. MS and NMR analysis showed the compounds to be 3-formyl-23-[O-(beta-D-glucopyranosyl)]rifamycin SV (2), 23-[O-(beta-D-glucopyranosyl)]rifampicin (3), 21-(O-phosphoryl)rifampicin (4) and 3-formyl-21-(O-phosphoryl)-rifamycin SV (5), respectively.Keywords
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